We all live in the toxic world. This is our reality. Although the human body has a sophisticated line of defense against toxins, more and more people, especially elderly and children, cannot adequately eliminate different toxins they are getting from the food, drinking water, air and drugs. If even just one phase of detoxification process in the body is broken or weak it enables poisons attack upon our bodies and brains.

 I.  Detoxication is the body’s cleanup process, the getting rid of unwanted harmful substances.  It is a natural biochemical procedure that goes in our body all the time. Humans have four phases of detoxication including: 1 - toxin isolation from the blood stream, 2- toxin conversion into water-soluble materials for much easier excretion, 3- conjugation toxins with special nutrients for  making them less toxic, and 4 – safe excretion of toxins from the body through GI tract, kidneys and skin.

  This natural defense process is taking place in our body every minute. It depends on our lever and kidney function, essential nutrients in food and friendly bacteria in the gut, volume and quality of drinking water, efficacy of oxygen supply and acid-alkaline balance in the organs and tissues.  If any of these factors for any reason are not adequate, the body cannot defend itself properly from poisoning.

 Therefore, the first step that we usually begin with is detection of the patient’s bodily weaknesses. I believe in Nature and God’s wisdom and suggest to eliminate problems that are making physiological processes and reactions not efficient.

There are numerous blood, urine and feces tests that are very helpful in making decision how to bring the patient’s body into balance naturally.

  Many people, especially children our days are anemic, allergic and sensitive to food, have slow thyroid and liver functions, numerous mineral and vitamin deficiencies, and bacterial dysbiosis, fungal or viral infection. No wonder they are delayed in growth and learning.

  Diet, nutrition, essential fatty and amino acids, vitamins, minerals, pure water, digestive enzymes, exercising, breathing and sleep pattern are major steps in helping the body to rebuild itself and maintain health.    

  II. Our bodies aren't very good at expelling heavy metals and toxins. The half-life of mercury in the brain, for example, is more than 10 years. Our ancestors weren't exposed to the heavy metals and toxic food we encounter, so a mechanism for effectively dealing with these toxins never evolved. To keep our bodies in optimal condition, we need to make sure that we aren't "overloaded" with toxins.

Detoxification is the process of enhanced elimination of significant amounts of endogenous and exogenous toxins from the body with the help of natural nutrients promoting organ drainage with more efficient conjugation of toxins and excretion. Most common nutrients are megadoses of vitamins, especially C and B, glutathione, zinc, magnesium, alpha-lipoic acid, carnosine, probiotics, etc. Some foods, like chlorella, cilantro, buckwheat, pectin, kefir, mushrooms, bran, etc, are able to move toxins out through the bowel.

III. Chelation is the process by which a metal or mineral (such as lead, mercury, arsenic, aluminum, etc.) is bonded to another substance so it can carry them away in urine, feces or sweat. For chelation, special chemicals (DMSA, DMPS, EDTA, TTFD, D-Penicillamine, etc.) are used. They  have affinity to specific heavy metals and minerals (mercury, lead, calcium, nickel, iron, etc.) The chelator binds to the metal molecule making it water-soluble and more easily excreted from the body. These agents are not natural but have shown safety and efficacy during many years of clinical experience. This procedure should be done only under trained physician supervision. We suggest chelation treatment only in case of diagnosed high level of toxicity and on basis of two previously mentioned steps, I and II.  

   Each chelating substance has its own benefits and possible side effects that you need to be aware of. The choice you make depends on your spectrum of heavy metal excretion through the liver and kidneys.

   It is known that some kids with learning disabilities and autism cannot excrete toxic metals accumulating them in their bodies.

   Many doctors now are using so called challenge test  for  heavy metal burden.   Although provocation with high chelator dosage is considered the most conclusive method to reveal heavy metal toxicity, I believe that it could be harmful for the patient, especially child due to higher amount of the chemical agent and harder push the poisons out to the blood stream.

   Each chelator has its own affinity to heavy metals that makes challenge test not accurate if you use not an appropriate agent or its incorrect dose. Another complexity of challenge test is that the chelator may preferentially bind to one metal first hiding or blocking other metals.

   Sometimes repeated administration of different agents is needed before significant toxin excretion occurs. We also need to keep in mind that even a healthy and normal people would tend to have a high results after challenge testing.

    Thus, a clinician needs to understand and interpret the test results carefully. I usually discuss all the limits of provocation test with my patients explaining them their urine and fecal test results and necessary steps we may take for proper diagnosis and treatment. There are several common routes for chelating agent administration: oral, transdermal, intravenous and rectal. Each one has its own benefits and side effects.    

Chelation therapy treatments are used for numerous diseases, including autism. They are also used in cardiovascular diseases, heavy metal toxicity, autoimmune diseases and many other conditions. When left untreated, heavy metal toxicity can lead to severe problems in both children and adults. For a detailed list of symptoms caused by different metals, please see here.

Nowadays, many holistic health practitioners offer chelation therapy. However, our chelation programs are different. We offer well-researched and tested gentle chelation methods that rebuild rather than destroy your body.

Oxygen Therapy becomes very popular in treatment of autistic children and kids with learning disabilities. It helps detoxification and increases brain supply with the essential nutrient O2. Oxygen deficiency that is often seen in kids with anemia  retards their growth and development.  Thou, even simple shallow breathing exercise, masking or pure oxygen inhalation may be very helpful. 

Our experience shows that these simple techniques could be compared in efficacy with expensive HBOT.  We suggest to monitor O2 level in the blood with oxymetry test and basing  on its results the choice of further therapy should be made.                                         

In some cases additional OZONE THERAPY could be considered with rectal insufflations.  (Ozone Therapy vs. Hyperbaric Oxygen Therapy- HBOT)  -  for more info

 

Dr. Koles Detoxification program: Our Detoxification programs include the following: Step 1: Identifying your personal needs - Medical testing One months before a detoxification and chelation program is started, Dr. Koles will order blood and allergy tests along with tests that assess your digestion, GI tract microbial flora, endocrine balance, nutritional status and toxicity levels. This will help us tailor your detoxification program and monitor your progress. Step 2: Pre-treatment - Achieving whole body balance As the base of our treatment plans, we first help you achieve a whole body balance. We believe that rapid chelation that doesn't take your overall health status can be potentially dangerous rather than helpful.  During the pre-treatment phase, we offer the following: Body metabolic  balancing This is essential for the proper function of all organs. After testing the main functions and  imbalances of the body we help to restore the patient's balance with the help of diet, nutrients, physical and breathing exercising. We use laser auriculotherapy (painless ear acupuncture) and/or classical acupuncture.These techniques will help balance your nervous system through a natural detoxification of physiological pathways (i.e. the liver, kidneys, skin). Opening of detoxification pathways To effectively deal with a heavy metal burden, you need an open detoxification pathway and you need chemical energy (ATP) within your cells. We provide supplementation with thiamin phosphate and niacin whenever necessary. Preventive treatment of intestinal imbalance We use probiotics, such as Mutaflor, Bificol, etc and naturopathic remedies to treat and prevent intestinal dysbiosis. We also use organic anti-fungal remedies, such as Lauricidin, which is a natural antimicrobial remedy. If you have Candida resistant to natural antifungal remedies (Lauricidin, oregano, Pau d‘Arco, etc), we can add the antifungal drug Nystatin to your treatment. It is safe and can be used even in children. We design a diet with different antiparasitic and antifungal foods, including organic garlic, cilantro, grape seed extract and pectin, ginger, flax seeds, chlorophyll, raw cabbage, buckwheat, sauerkraut, coconut and virgin coconut oil and so on. During this time, raw sweet fruit and juices should be avoided. Pre-treatment for magnetic therapy In some cases, we use magnetic therapy to enhance the detoxification process. If you are considering magnetic therapy for the heart or brain, a two-to-three month pre-treatment period is suggested. In our office, we use special pads and wraps with 4,000 Gauss negative magnetic field which increases ATP energy production within the cells. Sick cells that tend to be affected by heavy metals lack a positive charge. Once treated with a negative magnetic field, it will no longer lack in positive charge and allow itself to be over-calcified and metal poisoned.   Step 3: Chelation program Gentle chelation first - no EDTA push or oral Our research and experience shows that chelation should be never begin with any form of EDTA! Administering EDTA first can temporary, but significantly, increase mercury toxicity in the brain (up to 100 times, according to studies on the subject). Dr. Haley at University of Kentucky Medical Center conducted numerous studies on this. You can read them for more information. E.F. Duhr, J.C. Pendergrass, J.T. Slevin, and B.E. Haley, "HgEDTA Complex Inhibits GTP Interactions with the E-Site of Brain B-Tubulin," Toxicology and Applied Pharmacology 122, 273-280 (1993). Pendergrass, J.C. and Haley, B.E. Mercury: EDTA Complex Specifically Blocks Brain b-Tubulin-GTP Interactions: Similarity to Observations in Alzheimer"s Disease. pp98-105 in Status Quo and Perspective of Amalgam and Other Dental Materials (International Symposium Proceedings ed. by L. T. Friberg and G. N. Schrauzer) Georg Thieme Verlag, Stuttgart-New York (1995). Pendergrass, J. C., Haley, B.E., Vimy, M. J., Winfield, S.A. and Lorscheider, F.L. Mercury Vapor Inhalation Inhibits Binding of GTP to Tubulin in Rat Brain: Similarity to a Molecular Lesion in Alzheimer's Disease Brain. Neurotoxicology 18(2), 315-324 (1997). Nowadays, almost everyone has some mercury in their bodies. EDTA is a strong lead chelator. If IV EDTA used first, it will not only flush out huge amounts of lead, but also cause cells to be more prone to mercury damage. This can result in severe damage to important brain cell structures called "tubulins", leading to Alzheimer's-like dementia. If a person has no mercury toxicity and wants chelation for general treatment, such as for atherosclerosis, impotence, Alzheimer’s, diabetes, etc., we can begin with EDTA. However, we would test the patient for mercury toxicity first to avoid any potential side effects. Chelation with glutathione Glutathione should always be the first agent to consider since it's the body's natural chelating agent. A breakdown in the body's glutathione stores, synthesis and reclamation can be a prerequisite to developing mercury toxicity. Oral or transdermal DMSA/DMPS We recommend beginning with the classic protocol of oral DMSA (10 mg/kg ) or trasndermal DMSA for 3 days on followed by 11 days of mineral and nutrient replacement. To read more about DMSA and DMPS, please click here. Rectal DMSA or EDTA DMSA or EDTA rectal suppositories are added 3 months after initial DMSA (or DMPS, if preferred). We prefer to administer EDTA through suppositories because they're safer, gentler and more effective. The efficacy is 95% of IV procedure, the price is 50-75% less. You may do it at your convenience at home.  You may read more about rectal EDTA suppositories here. Before starting the rectal treatment, we first order tests to assess heavy metal toxicity in your urine, blood and feces. We also check liver and kidney function. IV Chelation - we do not offer this treatment considering it stressful for the patients, especially kids. Although many parents are looking for quick detox results, even a single IV procedure with a child body restriction could do more harm than good making a child nervous and in pain.    Step 4: Supportive therapy during and after chelation Bowel / intestinal support The primary route of excretion for mercury is the bowels. To minimize hepatic reuptake of mercury from the bowels, we use different binding agents, such as chitosan, charcoal, pectin and fiber. We also recommend to use a remedy called Allochol, which contains charcoal, bile acids and garlic. It has been safely tested by decades in Europe. To improve bowel function during chelation, we also design special cooking plans that utilize quick boiling and frying with no oils or butter. Bowel cleansing using mild natural laxatives, especially Lactulose, has also demonstrated effectiveness in reducing symptoms from heavy metal movement among our patients. Digestive systemic enzymes (nattokinase, trypsin, etc.) are important for elimination of the biofilm that covers bacterial and toxic accumulations along the bowel wall. Protecting the kidneys Kidney injury is a characteristic consequence of poisoning from heavy metals, especially mercury. Albuminuria (protein in the urine) is a classic result of this. We recommend push fluids along with a vegetarian, CF/GF, no sugar diet for kidney support. We also add organic Pol-Pola or Parsley containing herbal formulas if any sign of renal damage is present. In cases with renal damage, detoxification should be done very slowly with homeopathic and natural remedies, detox baths and far infrared sauna. Our patients are monitored throughout the detoxification process to ensure maximum health benefits. To learn more about different chelating agents we use, please click here.